Sodium Bicarbonate → HCID 178495390、化合物

HRID 1099130ノート

反応式

HRID 1099130 の反応式
[CH3:1][C:2]1[C:7]([CH2:8][S:9]([C:11]2[N-:19][C:18]3[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=3)[N:12]=2)=[O:10])=[N:6][CH:5]=[CH:4][C:3]=1[O:20][CH2:21][CH2:22][CH2:23][O:24][CH3:25].[Na+].C(=O)(O)[O-].[Na+]>C(OCC)(=O)C>[CH3:1][C:2]1[C:7]([CH2:8][S+:9]([O-:10])[C:11]2[NH:12][C:13]3[CH:14]=[CH:15][CH:16]=[CH:17][C:18]=3[N:19]=2)=[N:6][CH:5]=[CH:4][C:3]=1[O:20][CH2:21][CH2:22][CH2:23][O:24][CH3:25]

参加物

4

反応物 2

HCID 516892Sodium BicarbonateHCID 14720269Rabeprazole sodium

生成物 1

HCID 178495390HCID 178495390、化合物

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒

反応条件

温度
25 °C

実験手順

100 g of rabeprazole sodium salt (amorphous) is dissolved at approximately 25° C. in 450 ml of ethyl acetate. The solution is kept at approximately 25° C. and 8 ml of sodium bicarbonate saturated solution is added. The mixture is kept under stirring at approximately 25° C. for 25 hours. The resulting white solid is filtered by suction, washed with 100 ml of ethyl acetate and dried under vacuum at 45° C. The resulting product has the same physical characteristics of the product obtained in example 1.

後処理

  1. customis kept at approximately 25° C.
  2. filtrationThe resulting white solid is filtered by suction
  3. washwashed with 100 ml of ethyl acetate
  4. customdried under vacuum at 45° C

出典と根拠

ORDレコード
ord-d4bf717b240f4e089ad858e3b11183aa
出典データセット
uspto-grants-2012_03
特許番号
US08143409B2

反応ノート

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