[CH2:1]([N:4]([C:15]1[C:20](=[O:21])[N:19]2[C@H:22]([C:28](=[O:50])[NH:29][CH2:30][C:31]3[CH:36]=[CH:35][C:34]([C:37]([NH:39][C:40]([O:42][CH2:43][C:44]4[CH:49]=[CH:48][CH:47]=[CH:46][CH:45]=4)=[O:41])=[NH:38])=[CH:33][CH:32]=3)[CH2:23][C@@H:24]([CH2:25][CH:26]=[CH2:27])[C:18]2=[N:17][CH:16]=1)[C:5](=[O:14])[O:6][CH2:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[CH:2]=[CH2:3].[CH2:51]([C:54]1(CC=C)C2=NC=C(N(CC=C)C(OCC3C=CC=CC=3)=O)C(=O)N2[C@H](C(O)=O)C1)[CH:52]=C.Cl.C(OC(=O)NC(C1C=CC(CN)=CC=1)=N)C1C=CC=CC=1>>[CH2:1]([N:4]([C:15]1[C:20](=[O:21])[N:19]2[C@H:22]([C:28](=[O:50])[NH:29][CH2:30][C:31]3[CH:32]=[CH:33][C:34]([C:37]([NH:39][C:40]([O:42][CH2:43][C:44]4[CH:49]=[CH:48][CH:47]=[CH:46][CH:45]=4)=[O:41])=[NH:38])=[CH:35][CH:36]=3)[CH2:23][C:24]([CH2:54][CH:51]=[CH2:52])([CH2:25][CH:26]=[CH2:27])[C:18]2=[N:17][CH:16]=1)[C:5](=[O:14])[O:6][CH2:7][C:8]1[CH:9]=[CH:10][CH:11]=[CH:12][CH:13]=1)[CH:2]=[CH2:3]According to the procedure for the preparation of 28e, 29d (162 mg, 0.360 mmol) was coupled with [(4-aminomethyl-phenyl)-imino-methyl]-carbamic acid benzyl ester hydrochloride to afford after flash chromatography (66% EtOAc/hexanes) 105 mg (41%) of 29e. MS (ESI) 715.5 (M+H+), 737.5 (M+Na+).
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