Nitrosobenzene → (E)-N-hydroxy-3-(4-methoxyphenyl)-N-phenylacrylamide

HRID 1099339ノート

反応式

HRID 1099339 の反応式
C1CCN2C(=NCCC2)CC1.[CH3:12][O:13][C:14]1[CH:23]=[CH:22][C:17](/[CH:18]=[CH:19]/[CH:20]=[O:21])=[CH:16][CH:15]=1.[N:24]([C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1)=[O:25]>ClCCl>[OH:25][N:24]([C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1)[C:20](=[O:21])/[CH:19]=[CH:18]/[C:17]1[CH:22]=[CH:23][C:14]([O:13][CH3:12])=[CH:15][CH:16]=1

参加物

5

反応物 3

HCID 11473NitrosobenzeneHCID 811841,8-Diazabicyclo(5.4.0)undec-7-eneHCID 641294p-METHOXYCINNAMALDEHYDE

生成物 1

HCID 14740422(E)-N-hydroxy-3-(4-methoxyphenyl)-N-phenylacrylamide

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

DBU (7.5 mg, 0.05 mmol) was added under argon to a solution of (E)-4-methoxycinnamaldehyde (162 mg, 1 mmol), nitrosobenzene (107 mg, 1 mmol) and catalyst (18.2 mg, 0.05 mmol) in dichloromethane (5 mL). The reaction mixture was stirred at room temperature for 10 min. The solvent was removed under vacuum, and the residue was purified by flash silica gel column chromatography using hexane and ethyl acetate as the eluents.

後処理

  1. customThe solvent was removed under vacuum
  2. customthe residue was purified by flash silica gel column chromatography

出典と根拠

ORDレコード
ord-49154436f95d40fab3329f7a5798f36f
出典データセット
uspto-grants-2012_03
特許番号
US08143423B2

反応ノート

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