Benzaldehyde → HCID 25115948、化合物
反応式
C1CCN2C(=NCCC2)CC1.[CH:12](=[O:19])[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1.[F:20][C:21]1[CH:26]=[CH:25][CH:24]=[C:23]([F:27])[C:22]=1[N:28]=[O:29]>ClCCl>[F:20][C:21]1[CH:26]=[CH:25][CH:24]=[C:23]([F:27])[C:22]=1[N:28]([OH:29])[C:12](=[O:19])[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1参加物
5
実験手順
DBU (15 mg, 0.1 mmol) was added under argon to a solution of benzaldehyde (106 mg, 1 mmol), 1,3-difluoro-2-nitrosobenzene (143 mg, 1 mmol) and catalyst (36.4 mg, 0.1 mmol) in dichloromethane (5 mL). The reaction mixture was stirred at room temperature for 60 min. The solvent was removed under vacuum, and the residue was purified by flash silica gel column chromatography using hexane and ethyl acetate as the eluents.
後処理
- customThe solvent was removed under vacuum
- customthe residue was purified by flash silica gel column chromatography
出典と根拠
- ORDレコード
- ord-9845a078227d46a48a2bbb2a0a23edc9
- 出典データセット
- uspto-grants-2012_03
- 特許番号
- US08143423B2
反応ノート
読み込み中…