Water → 8-Methylcoumarin

HRID 1099362ノート

反応式

HRID 1099362 の反応式
[OH:1][C:2]1[C:9]([CH3:10])=[CH:8][CH:7]=[CH:6][C:3]=1[CH:4]=O.[C:11]([O-])(=[O:13])[CH3:12].[Na+].C(OC(=O)C)(=O)C.O>CCCCCC>[CH3:10][C:9]1[CH:8]=[CH:7][CH:6]=[C:3]2[C:2]=1[O:1][C:11](=[O:13])[CH:12]=[CH:4]2

参加物

6

反応物 4

HCID 962WaterHCID 7918Acetic AnhydrideHCID 517045Sodium AcetateHCID 5227773-Methylsalicylaldehyde

生成物 1

HCID 157348-Methylcoumarin収率 85%

試薬・触媒・溶媒 1

HCID 8058Hexane溶媒

反応条件

温度
177.5 °C

実験手順

The suspension of 2-Hydroxy-3-methyl benzaldehyde (30 gm, 0.220 mole) and anhydrous Sodium acetate (45 gm, 0.55 mole) in Acetic anhydride (45 gm, 0.44 mole) was heated at 175-180° C. for 6 hours. The reaction mixture was cooled; water (150 ml) and Hexane (60 ml) were added. It was stirred for an hour and filtered. The obtained solid was stirred with Diethyl ether (30 ml). Finally the suspension was filtered and dried to give 19 gm desired product.

後処理

  1. temperatureThe reaction mixture was cooled
  2. filtrationfiltered
  3. stirringThe obtained solid was stirred with Diethyl ether (30 ml)
  4. filtrationFinally the suspension was filtered
  5. customdried

出典と根拠

ORDレコード
ord-d2f367b4660d452b9b4537e0f3e82b7a
出典データセット
uspto-grants-2012_03
特許番号
US08143424B2

反応ノート

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