Water → 4-Methoxy-5-methyl-indan-1-one

HRID 1099371ノート

反応式

HRID 1099371 の反応式
[OH:1][C:2]1[C:10]([CH3:11])=[CH:9][CH:8]=[C:7]2[C:3]=1[CH2:4][CH2:5][C:6]2=[O:12].[C:13](=O)([O-])[O-].[K+].[K+].S(OC)(OC)(=O)=O.O>CN(C)C=O>[CH3:13][O:1][C:2]1[C:10]([CH3:11])=[CH:9][CH:8]=[C:7]2[C:3]=1[CH2:4][CH2:5][C:6]2=[O:12]

参加物

6

反応物 4

HCID 962WaterHCID 6497Dimethyl SulfateHCID 11430Potassium CarbonateHCID 668122914-Hydroxy-5-methyl-2,3-dihydro-1H-inden-1-one

生成物 1

HCID 552973254-Methoxy-5-methyl-indan-1-one収率 82.9%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

反応条件

温度
62.5 °C

実験手順

To a suspension of 4-Hydroxy-5-methyl-indan-1-one (50.0 gm, 0.308 mole) and Potassium carbonate (127.0 gm, 0.928 mole) in Dimethylformamide (250 ml), Dimethyl sulphate (90 ml, 0.928 mole) was added at 0° C. The reaction mixture was heated at 60-65° C. and stirred for 16 hours. The reaction mixture was poured into water (1 liter) and extracted with Ethylacetate (3×250 ml). The organic layer was dried over Sodium sulphate and distilled under vacuum to give 10.0 gm of crude product which was purified by column chromatography using Hexane as a mobile phase. The collected fractions were distilled under vacuum to give 45.0 gm of desired product as a viscous oil.

後処理

  1. additionwas added at 0° C
  2. extractionextracted with Ethylacetate (3×250 ml)
  3. dry with materialThe organic layer was dried over Sodium sulphate
  4. distillationdistilled under vacuum
  5. customto give 10.0 gm of crude product which
  6. customwas purified by column chromatography
  7. distillationThe collected fractions were distilled under vacuum

出典と根拠

ORDレコード
ord-5185eb1bf97744f6ad70218e360e0109
出典データセット
uspto-grants-2012_03
特許番号
US08143424B2

反応ノート

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