2-(1,3-Dioxaindan-5-yl)ethan-1-ol → N-{4-[2-(1,3-Benzodioxol-5-yl)ethoxy]benzoyl}glycine

HRID 1099563

反応式

HRID 1099563 の反応式
C([O:5][C:6](=[O:18])[CH2:7][NH:8][C:9](=[O:17])[C:10]1[CH:15]=[CH:14][C:13]([OH:16])=[CH:12][CH:11]=1)(C)(C)C.[O:19]1[C:23]2[CH:24]=[CH:25][C:26]([CH2:28][CH2:29]O)=[CH:27][C:22]=2[O:21][CH2:20]1>>[O:19]1[C:23]2[CH:24]=[CH:25][C:26]([CH2:28][CH2:29][O:16][C:13]3[CH:12]=[CH:11][C:10]([C:9]([NH:8][CH2:7][C:6]([OH:5])=[O:18])=[O:17])=[CH:15][CH:14]=3)=[CH:27][C:22]=2[O:21][CH2:20]1

参加物

3

反応物 2

HCID 27598462-(1,3-Dioxaindan-5-yl)ethan-1-olHCID 10682169N-(4-Hydroxybenzoyl)glycine tert-butyl ester

生成物 1

HCID 66812435N-{4-[2-(1,3-Benzodioxol-5-yl)ethoxy]benzoyl}glycine収率 87%

実験手順

The same reaction as in Example 1 (1b) was conducted using N-(4-hydroxybenzoyl)glycine tert-butyl ester (300 mg, 1.19 mmol) prepared in Example 1 (1a) and 2-(1,3-benzodioxol-5-yl)ethanol (which is the compound disclosed in Tetrahedron, (2003), 59, 3369-3378, 239 mg, 1.44 mmol) to give 356 mg of the title compound (pale red powder, yield: 87%).

出典と根拠

ORDレコード
ord-180e66b8934142c8998fa5dc75fce500
出典データセット
uspto-grants-2012_03
特許番号
US08143446B2

関連ノート

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