(6R,8S)-[3-(allyl-benzyloxycarbonyl-amino)-8-methyl-4-oxo-6-phenylcarbamoyl-4,6,7,8-tetrahydro-pyrrolo[1,2-a]pyrimidin-8-yl]-acetic acid tert-butyl ester → (6R,8S)-[3-(allyl-benzyloxycarbonyl-amino)-6-(tert-butoxycarbonyl-phenyl-aminocarbonyl)-8-methyl-4-oxo-4,6,7,8-tetrahydro-pyrrolo[1,2-a]pyrimidin-8-yl]-acetic Acid tert-butyl Ester
反応式
[CH2:1]([O:8][C:9](=[O:44])[N:10]([CH2:41][CH:42]=[CH2:43])[C:11]1[C:16](=[O:17])[N:15]2[C@H:18]([C:25]([N:27]([C:34]([O:36][C:37]([CH3:40])([CH3:39])[CH3:38])=[O:35])[C:28]3[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=3)=[O:26])[CH2:19][C@:20](N=[N+]=[N-])([CH3:21])[C:14]2=[N:13][CH:12]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:45]([O:49][C:50](=[O:86])[CH2:51][C@@]1(C)C2=NC=C(N(CC=C)C(OCC3C=CC=CC=3)=O)C(=O)N2[C@@H](C(=O)NC2C=CC=CC=2)C1)([CH3:48])([CH3:47])[CH3:46]>>[C:45]([O:49][C:50](=[O:86])[CH2:51][C@@:20]1([CH3:21])[C:14]2=[N:13][CH:12]=[C:11]([N:10]([CH2:41][CH:42]=[CH2:43])[C:9]([O:8][CH2:1][C:2]3[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=3)=[O:44])[C:16](=[O:17])[N:15]2[C@@H:18]([C:25]([N:27]([C:34]([O:36][C:37]([CH3:40])([CH3:38])[CH3:39])=[O:35])[C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=2)=[O:26])[CH2:19]1)([CH3:48])([CH3:47])[CH3:46]参加物
3
反応物 2
HCID 69600880(6R,8S)-[3-(allyl-benzyloxycarbonyl-amino)-8-methyl-4-oxo-6-phenylcarbamoyl-4,6,7,8-tetrahydro-pyrrolo[1,2-a]pyrimidin-8-yl]-acetic acid tert-butyl ester
HCID 86590670(6S,8R)-allyl-[8-azido-6-(tert-butoxycarbonyl-phenyl-aminocarbonyl)-8-methyl-4-oxo-4,6,7,8-tetrahydro-pyrrolo[1,2-a]pyrimidin-3-yl]-carbamic Acid Benzyl Ester生成物 1
実験手順
Following a procedure similar to that for the preparation of intermediate 18e, intermediate 38a (435.9 mg, 0.76 mmol), was protected to give 418.9 mg (82%) of intermediate 38b. MS (ESI) 673.4 (M+H+), 695.3 (M+Na+).
出典と根拠
- ORDレコード
- ord-a42c8550554944cb81be6dab778dd8cf
- 出典データセット
- uspto-grants-2006_08
- 特許番号
- US07094783B2
関連ノート
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