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Maleimide → tetrahydropyrrolo[3,4-c]carbazole-1,3(2H, 3aH)-dione
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Maleimide | HCID 10935 | — |
| 反応物 | 2-{2-[2-(2-Chlorophenyl)ethenyl]-5-methoxy-1H-indol-1-yl}ethanol | HCID 73857732 | — |
| 生成物 | tetrahydropyrrolo[3,4-c]carbazole-1,3(2H, 3aH)-dione | HCID 131725903 | 79% |
反応手順
Reaction of 2-{2-[2-(2-Chlorophenyl)ethenyl]-5-methoxy-1H-indol-1-yl}ethanol (III; Ar=2-chlorophenyl, R10═CH2CH2OH) (44) prepared according to example 41 with maleimide according to the procedure described in example 68 gave 4-(2-Chlorophenyl)-6-(2-hydroxyethyl)-9-methoxy-4,5,6,1 Oc-tetrahydropyrrolo[3,4-c]carbazole-1,3(2H, 3aH)-dione (IV; Ar=2-chlorophenyl, R10═CH2CH2OH) (45) in a 79% yield as an oily solid, which was used without further purification.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07094798B1 |
| 出典データセット | uspto-grants-2006_08 |
| ORD ID | ord-7c0e1b6db3f34a84be1395fb66bcc132 |
| 出典メモ | uspto-grants-2006_08 |