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Acetyl bromide → N-Formyl-2-(4-acetylphenyl) ethanamine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Acetyl bromide | HCID 10482 | — |
| 反応物 | Formamide, N-(2-phenylethyl)- | HCID 140995 | — |
| 反応物 | Aluminum(III) Chloride | HCID 6451240 | — |
| 溶媒 | 1,2-Dichloroethane | HCID 11 | — |
| 生成物 | N-Formyl-2-(4-acetylphenyl) ethanamine | HCID 20556093 | — |
反応手順
This was prepared in an identical manner to the compound described in Description 10 using N-formyl-2-phenylethanamine (95 g), acetylbromide (128 ml), aluminium chloride (288 g) in 1,2-dichloroethane (900 ml). 25 g of the crude produce was chromatographed on Kieselgel 60 (1 Kg). Elution with 1% methanol-chloroform gave the title compound as an oil (18 g). τ(CDCl3) 7.42 (3H, s), 7.1 (2H, t, J=7 Hz), 6.5 (2H, m), 3.45 (1H, broad), 2.7 (2H, d, J=8 Hz) 2.1 (2H, d, J=8 Hz), 1.9 (1H, s).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04309443 |
| 出典データセット | uspto-grants-1982_01 |
| ORD ID | ord-433aaae29f2a45c1bf0099ec91d1387e |
| 出典メモ | uspto-grants-1982_01 |