4-Aminopyridine → HCID 12822543、化合物

HRID 1105680ノート

反応式

HRID 1105680 の反応式
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([CH:9]2[CH2:14][C:13](=[O:15])[O:12][C:10]2=O)=[CH:5][CH:4]=1.[NH2:16][C:17]1[CH:22]=[CH:21][N:20]=[CH:19][CH:18]=1.C1(C)C(C)=CC=CC=1>O>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([CH:9]2[CH2:14][C:13](=[O:15])[N:16]([C:17]3[CH:22]=[CH:21][N:20]=[CH:19][CH:18]=3)[C:10]2=[O:12])=[CH:7][CH:8]=1

参加物

5

反応物 3

HCID 17274-AminopyridineHCID 7237O-XyleneHCID 144728493-(4-Methoxy-phenyl)-dihydro-furan-2,5-dione

生成物 1

HCID 12822543HCID 12822543、化合物

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

The starting material is prepared as follows: The mixture of 57.9 g of 2-(p-methoxyphenyl)-succinic anhydride, 26.3 g of 4-aminopyridine and 500 ml of xylene is refluxed on a water separator while stirring for 6.5 hours. The hot solution is decanted off, cooled, filtered and the residue recrystallized from ethanol, to yield the 3-(p-methoxyphenyl)-1-(4-pyridyl)-pyrrolidin-2,5-dione melting at 179°-180°; its 3,4-dimethoxy-analog melts at 172°14 174°.

後処理

  1. customThe starting material is prepared
  2. customThe hot solution is decanted off
  3. temperaturecooled
  4. filtrationfiltered
  5. customthe residue recrystallized from ethanol

出典と根拠

ORDレコード
ord-a1853fec00264953ab0b767329d0f4a7
出典データセット
uspto-grants-1982_01
特許番号
US04309541

反応ノート

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