Acetyl isothiocyanate → HCID 13023177、化合物

HRID 1105833ノート

反応式

HRID 1105833 の反応式
[C:1]([NH:5][C:6](=[S:23])[NH:7][C:8]1[CH:9]=[C:10]([CH:19]=[CH:20][C:21]=1[NH2:22])[C:11]([C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)=[O:12])([O:3][CH3:4])=[O:2].[C:24]([N:27]=[C:28]=[S:29])(=[O:26])[CH3:25]>CC(C)=O>[C:1]([NH:5][C:6](=[S:23])[NH:7][C:8]1[CH:9]=[C:10]([CH:19]=[CH:20][C:21]=1[NH:22][C:28]([NH:27][C:24](=[O:26])[CH3:25])=[S:29])[C:11]([C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)=[O:12])([O:3][CH3:4])=[O:2]

参加物

4

反応物 2

HCID 128851Acetyl isothiocyanateHCID 30369724-Amino-3-(3'-methoxycarbonyl-2'-thioureido)benzophenone

生成物 1

HCID 13023177HCID 13023177、化合物収率 54%

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

To a suspension of 3-(3-carbomethoxythioureido)-4-aminobenzophenone (1.2 g.; 0.0036 mole) in acetone (15 ml.) is added acetyl isothiocyanate (0.37 g.; 0.0036 mole). The reaction mixture is heated to reflux and then allowed to stand at room temperature for 18 hours. The product is collected by filtration, washed successively to afford 0.85 g. (54% yield) of 3-(3-carbomethoxythioureido)-4-(3-acetylthioureido)benzophenone, m.p. 210° C., dec.

後処理

  1. temperatureThe reaction mixture is heated
  2. temperatureto reflux
  3. filtrationThe product is collected by filtration
  4. washwashed successively
  5. customto afford 0.85 g

出典と根拠

ORDレコード
ord-e84afdf185344eae9b18d65a1ee6ca8c
出典データセット
uspto-grants-1982_01
特許番号
US04310537

反応ノート

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