Benzoyl chloride → HCID 13023186、化合物

HRID 1105837ノート

反応式

HRID 1105837 の反応式
[C:1]([NH:5][C:6](=[S:23])[NH:7][C:8]1[CH:9]=[C:10]([CH:19]=[CH:20][C:21]=1[NH2:22])[C:11]([C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)=[O:12])([O:3][CH3:4])=[O:2].[C:24](Cl)(=[O:31])[C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1>C1(C)C=CC=CC=1>[C:1]([NH:5][C:6](=[S:23])[NH:7][C:8]1[CH:9]=[C:10]([CH:19]=[CH:20][C:21]=1[NH:22][C:24](=[O:31])[C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1)[C:11]([C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)=[O:12])([O:3][CH3:4])=[O:2]

参加物

4

反応物 2

HCID 7412Benzoyl chlorideHCID 30369724-Amino-3-(3'-methoxycarbonyl-2'-thioureido)benzophenone

生成物 1

HCID 13023186HCID 13023186、化合物収率 65%

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

To a suspension of 3-(3-carbomethoxythioureido)-4-aminobenzophenone (3.29 g.) in toluene (200 ml.) is added benzoyl chloride (1.4 g.). The mixture is refluxed for 18 hours, cooled to room temperature and the precipitate collected, washed with hexane and dried to afford 2.8 g. (65% yield) of 3-(3-carbomethoxythioureido)-4-benzamidobenzophenone as a gray solid, m.p. 191°-192° C., dec.

後処理

  1. temperatureThe mixture is refluxed for 18 hours
  2. customthe precipitate collected
  3. washwashed with hexane
  4. customdried
  5. customto afford 2.8 g

出典と根拠

ORDレコード
ord-1aac0dfee42d4aa389293573138ab584
出典データセット
uspto-grants-1982_01
特許番号
US04310537

反応ノート

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