Methoxycarbonyl isothiocyanate → HCID 54270269、化合物

HRID 1105840ノート

反応式

HRID 1105840 の反応式
[NH2:1][C:2]1[CH:3]=[C:4]([CH:13]=[CH:14][C:15]=1[NH:16][CH2:17][CH2:18][CH2:19][CH3:20])[C:5]([C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)=[O:6].[C:21]([N:25]=[C:26]=[S:27])([O:23][CH3:24])=[O:22]>C(OCC)C>[C:21]([NH:25][C:26](=[S:27])[NH:1][C:2]1[CH:3]=[C:4]([CH:13]=[CH:14][C:15]=1[NH:16][CH2:17][CH2:18][CH2:19][CH3:20])[C:5]([C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)=[O:6])([O:23][CH3:24])=[O:22]

参加物

4

反応物 2

HCID 552246Methoxycarbonyl isothiocyanateHCID 54315355HCID 54315355、化合物

生成物 1

HCID 54270269HCID 54270269、化合物収率 10.2%

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒

実験手順

To a solution of 3-amino-4-n-butylaminobenzophenone (2.38 g.) in diethyl ether (200 ml.) is added carbomethoxy isothiocyanate (1.4 g.). The reaction mixture is stirred at room temperature for three hours. The product is collected by filtration and dried to afford 0.2 g. of product, m.p. 160°-162° C., dec. The filtrate is allowed to stand overnight at room temperature and a second crop is collected amounting to 0.15 g., m.p. 162° C., dec. The total amount of 3-(3-carbomethoxythioureido)-4-n-butylaminobenzophenone obtained is 0.35 g. (10.2% yield).

後処理

  1. filtrationThe product is collected by filtration
  2. customdried
  3. customto afford 0.2 g
  4. waitto stand overnight at room temperature
  5. customa second crop is collected amounting to 0.15 g

出典と根拠

ORDレコード
ord-776f5aaee6834c3b9e4d24dcc73faa33
出典データセット
uspto-grants-1982_01
特許番号
US04310537

反応ノート

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