Ethanol → Ethyl 2-[4-(4-chlorophenyl)benzyloxy]-2-phenylacetate

HRID 1105873ノート

反応式

HRID 1105873 の反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:25]=[CH:24][C:11]([CH2:12][O:13][CH:14]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)[C:15]([OH:17])=[O:16])=[CH:10][CH:9]=2)=[CH:4][CH:3]=1.S(=O)(=O)(O)O.C(=O)(O)[O-].[CH2:35](O)[CH3:36]>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:25]=[CH:24][C:11]([CH2:12][O:13][CH:14]([C:18]3[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=3)[C:15]([O:17][CH2:35][CH3:36])=[O:16])=[CH:10][CH:9]=2)=[CH:4][CH:3]=1

参加物

5

反応物 4

HCID 702EthanolHCID 769Bicarbonate IonHCID 1118Sulfuric AcidHCID 98633512-[4-(4-Chlorophenyl)benzyloxy]-2-phenylacetic acid

生成物 1

HCID 20555293Ethyl 2-[4-(4-chlorophenyl)benzyloxy]-2-phenylacetate

実験手順

A solution of 2-[4-(4-chlorophenyl)benzyloxy]-2-phenylacetic acid (8.0 g.) in ethanol (200 ml.) containing concentrated sulphuric acid (1 ml.) was heated under reflux for 90 minutes, then cooled to room temperature, and carefully neutralised by addition of an excess of saturated aqueous bicarbonate solution. The mixture obtained was evaporated and the residue extracted thoroughly with ethyl acetate. The combined extracts were washed with water, dried (MgSO4) and evaporated to give ethyl 2-[4-(4-chlorophenyl)benzyloxy]-2-phenylacetate (6.65 g.), m.p. 50°-51° C.

後処理

  1. temperaturewas heated
  2. temperatureunder reflux for 90 minutes
  3. customThe mixture obtained
  4. customwas evaporated
  5. extractionthe residue extracted thoroughly with ethyl acetate
  6. washThe combined extracts were washed with water
  7. dry with materialdried (MgSO4)
  8. customevaporated

出典と根拠

ORDレコード
ord-849d0e41554c4a528911e78e602a55cf
出典データセット
uspto-grants-1982_01
特許番号
US04310544

反応ノート

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