Isopropanol → Isopropyl 4-[15-(trifluoromethyl)pentadecylamino]benzoate

HRID 1105900ノート

反応式

HRID 1105900 の反応式
[F:1][C:2]([F:29])([F:28])[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][NH:18][C:19]1[CH:27]=[CH:26][C:22]([C:23]([OH:25])=[O:24])=[CH:21][CH:20]=1.B(F)(F)F.CCOCC.[CH:39](O)([CH3:41])[CH3:40]>>[F:1][C:2]([F:28])([F:29])[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][NH:18][C:19]1[CH:27]=[CH:26][C:22]([C:23]([O:25][CH:39]([CH3:41])[CH3:40])=[O:24])=[CH:21][CH:20]=1

参加物

4

反応物 3

HCID 3776IsopropanolHCID 8000Boron trifluoride etherateHCID 128316104-[15-(Trifluoromethyl)pentadecylamino]benzoic acid

生成物 1

HCID 20549354Isopropyl 4-[15-(trifluoromethyl)pentadecylamino]benzoate

実験手順

A solution of 50.5 g of 4-[15-(trifluoromethyl)pentadecylamino]benzoic acid and 34.4 ml. of boron trifluoride etherate in 200 ml. of isopropyl alcohol is stirred under reflux for 44 hours, allowed to cool, and poured into 1.20 liters of ice cold 5% aqueous sodium carbonate solution. The white solid is collected by filtration and recrystallized from benzene-ethanol to yield the product as a white solid.

後処理

  1. temperatureunder reflux for 44 hours
  2. temperatureto cool
  3. filtrationThe white solid is collected by filtration
  4. customrecrystallized from benzene-ethanol

出典と根拠

ORDレコード
ord-e11073968e634e918996f8e07c194718
出典データセット
uspto-grants-1982_01
特許番号
US04310545

反応ノート

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