Tert-Butylamine → 1-{4-[2-(Cyclopropylmethoxy)-ethoxy]phenoxy}-3-t-butylamino-propan-2-ol

HRID 1106094ノート

反応式

HRID 1106094 の反応式
[CH:1]1([CH2:4][O:5][CH2:6][CH2:7][O:8][C:9]2[CH:19]=[CH:18][C:12]([O:13][CH2:14][CH:15]3[O:17][CH2:16]3)=[CH:11][CH:10]=2)[CH2:3][CH2:2]1.[C:20]([NH2:24])([CH3:23])([CH3:22])[CH3:21]>>[CH:1]1([CH2:4][O:5][CH2:6][CH2:7][O:8][C:9]2[CH:19]=[CH:18][C:12]([O:13][CH2:14][CH:15]([OH:17])[CH2:16][NH:24][C:20]([CH3:23])([CH3:22])[CH3:21])=[CH:11][CH:10]=2)[CH2:3][CH2:2]1

参加物

3

反応物 2

HCID 6385Tert-ButylamineHCID 150353032-((4-(2-(Cyclopropylmethoxy)ethoxy)phenoxy)methyl)oxirane

生成物 1

HCID 30474911-{4-[2-(Cyclopropylmethoxy)-ethoxy]phenoxy}-3-t-butylamino-propan-2-ol収率 74%

実験手順

Following the procedure of Example I, 1-{4-[2-(cyclopropylmethoxy)-ethoxy]-phenoxy}-2,3-epoxy-propane is prepared and then treated with t-butylamine. 7.6 g (yield=74%) of crude 1-{4-[2-(cyclopropylmethoxy)-ethoxy]phenoxy}-3-t-butylamino-propan-2-ol are thus obtained, and this material is converted to the fumarate by mixing stoichiometric amounts of the base and of the acid in solution in isopropanol. The neutral fumarate which has precipitated is filtered off and recrystallised from ethanol (yield=80%), M.p.=158°-160° C.

後処理

  1. customis prepared

出典と根拠

ORDレコード
ord-1eb85eb6b09342ea8ccc7035332251d7
出典データセット
uspto-grants-1982_01
特許番号
US04311708

反応ノート

読み込み中…