Glycerol → 2,3-Dihydroxypropyl 4-(16-bromohexadecylamino)benzoate

HRID 1106155ノート

反応式

HRID 1106155 の反応式
[Br:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][NH:18][C:19]1[CH:27]=[CH:26][C:22]([C:23]([OH:25])=[O:24])=[CH:21][CH:20]=1.[OH:28][CH2:29][CH:30]([CH2:32]O)[OH:31].B(F)(F)F.CCOCC>C1(C)C=CC=CC=1>[Br:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][NH:18][C:19]1[CH:20]=[CH:21][C:22]([C:23]([O:25][CH2:32][CH:30]([OH:31])[CH2:29][OH:28])=[O:24])=[CH:26][CH:27]=1

参加物

5

反応物 3

HCID 753GlycerolHCID 8000Boron trifluoride etherate2 回HCID 204825194-(16-Bromohexadecylamino)benzoic acid

生成物 1

HCID 204825222,3-Dihydroxypropyl 4-(16-bromohexadecylamino)benzoate

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

A solution of 11.8 g. of 4-(16-bromohexadecylamino)benzoic acid, 1.00 g. of glycerol, and 5.35 ml. of boron trifluoride etherate in 200 ml. of toluene is stirred under reflux for 48 hours. The solution is treated with an additional 5.35 ml. of boron trifluoride etherate and refluxing for 120 hours. Dilution with water and methylene chloride followed by filtration affords 2,3-dihydroxypropyl 4-(16-bromohexadecylamino)benzoate as a white solid.

後処理

  1. temperatureunder reflux for 48 hours
  2. additionThe solution is treated with an additional 5.35 ml
  3. filtrationDilution with water and methylene chloride followed by filtration

出典と根拠

ORDレコード
ord-6a0e262ff1454079af21af38bf274fdb
出典データセット
uspto-grants-1982_01
特許番号
US04311846

反応ノート

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