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Ethyl Acetate → 1-(2-Amino-1-oxo-3-phenylpropyl)-4-(4-fluorophenyl)piperazine hydrochloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ethyl Acetate | HCID 8857 | — |
| 反応物 | Hydrogen chloride-ethyl acetate | HCID 21866389 | — |
| 反応物 | 1,1-Dimethylethyl 2-(4-(4-fluorophenyl)-1-piperazinyl)-2-oxo-1-(phenylmethyl)ethylcarbamate | HCID 53804735 | — |
| 生成物 | 1-(2-Amino-1-oxo-3-phenylpropyl)-4-(4-fluorophenyl)piperazine hydrochloride | HCID 18545010 | 96.1% |
反応手順
To a solution of 1,1-dimethylethyl 2-(4-(4-fluorophenyl)-1-piperazinyl)-2-oxo-1-(phenylmethyl)ethylcarbamate (2.7 g, 6.3 mmol) in ethyl acetate (20 mmol) under ice-cooling was dropwise added 4N HCl/ethyl acetate (20 ml), and the mixture was stirred at room temperature overnight. The resulting crystals were recovered by filtration and recrystallized from ethanol-diethyl ether to give 1-(2-amino-1-oxo-3-phenylpropyl)-4-(4-fluorophenyl)piperazine hydrochloride (2.2 g, 96.1%) as pale-yellow crystals.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06057290 |
| 出典データセット | uspto-grants-2000_05 |
| ORD ID | ord-4ed625e9de4341d092adb9d460a29452 |
| 出典メモ | uspto-grants-2000_05 |