化工社化工社 化学情報印刷レポート · 研究参考用
Sodium Hydroxide → 5-Hydroxy-2-methoxypyridine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | 5-Acetoxy-2-methoxypyridine | HCID 22451566 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | 5-Hydroxy-2-methoxypyridine | HCID 11622335 | 53.4% |
反応手順
To a solution of the 5-acetoxy-2-methoxypyridine(600 mg, 3.59 mmol) in MeOH(10 mL) was added 1M aq. NaOH(10 mL, 10 mmol). After stirring at r.t. for 30 min, volatile solvent was removed in vacuo, acidified with HOAc and extracted with CHCl3(3 x). The combined CHCl3 extracts were washed with H2O, dried(anhydrous MgSO4) and evaporated to give the title compound as a brown oil(240 mg, solidified on standing).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06057319 |
| 出典データセット | uspto-grants-2000_05 |
| ORD ID | ord-a0fc49c836644fa49a69eaac378a3d51 |
| 出典メモ | uspto-grants-2000_05 |