Hydrochloric Acid → 2-(4-Methyl-3-methanesulfonylaminophenoxy)-acetimidic acid ethyl ester hydrochloride

HRID 1106717ノート

反応式

HRID 1106717 の反応式
[C:1]([CH2:3][O:4][C:5]1[CH:6]=[CH:7][C:8]([CH3:16])=[C:9]([NH:11][S:12]([CH3:15])(=[O:14])=[O:13])[CH:10]=1)#[N:2].[ClH:17].[CH2:18]([OH:20])[CH3:19]>ClCCl>[ClH:17].[CH2:18]([O:20][C:1](=[NH:2])[CH2:3][O:4][C:5]1[CH:6]=[CH:7][C:8]([CH3:16])=[C:9]([NH:11][S:12]([CH3:15])(=[O:14])=[O:13])[CH:10]=1)[CH3:19]

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 702EthanolHCID 18789597N-(5-cyanomethoxy-2-methylphenyl)-methanesulfonamide

生成物 1

HCID 693516472-(4-Methyl-3-methanesulfonylaminophenoxy)-acetimidic acid ethyl ester hydrochloride

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

N-(5-Cyanomethoxy-2-methylphenyl)-methanesulfonamide (3.48 g) was dissolved in a mixture of 70 ml of dichloromethane and 3.5 ml of ethanol. The reaction mixture was cooled in an ice bath, saturated with hydrogen chloride gas (Matheson, Newark, Calif.), and slowly allowed to come to room temperature and kept there for 16 hours. The solvent was evaporated leaving 5.2 g of 2-(4-methyl-3-methanesulfonylaminophenoxy)-acetimidic acid ethyl ester hydrochloride. ##STR77##

後処理

  1. customto come to room temperature
  2. customThe solvent was evaporated

出典と根拠

ORDレコード
ord-c4f77a55ac6245baaf763bafcae6900a
出典データセット
uspto-grants-2000_05
特許番号
US06057349

反応ノート

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