N-methanesulfonyl-6-nitroindole → N-methanesulfonyl-6-aminoindole
反応式
[CH3:1][S:2]([N:5]1[C:13]2[C:8](=[CH:9][CH:10]=[C:11]([N+:14]([O-])=O)[CH:12]=2)[CH:7]=[CH:6]1)(=[O:4])=[O:3]>CO.[Pt]=O>[CH3:1][S:2]([N:5]1[C:13]2[C:8](=[CH:9][CH:10]=[C:11]([NH2:14])[CH:12]=2)[CH:7]=[CH:6]1)(=[O:4])=[O:3]参加物
4
実験手順
A mixture of N-methanesulfonyl-6-nitroindole (2.52 g, 10.5 mmol, from above) and platinum oxide (119 mg, 0.52 mmol) in 100 ml of methanol was hydrogenated in a Parr apparatus for approximately 1 hr until a constant pressure was obtained (42 psi H2 initially). The catalyst was removed by filtration (Whatman GF/F filter) and the filtrate was concentrated by rotary evaporation to give N-methanesulfonyl-6-aminoindole, an oil which solidified on standing under an argon atmosphere.
後処理
- customwas obtained (42 psi H2 initially)
- customThe catalyst was removed by filtration (Whatman GF/F filter)
- concentrationthe filtrate was concentrated by rotary evaporation
出典と根拠
- ORDレコード
- ord-c28458a67c084ea3a2a1a41b8b617dbe
- 出典データセット
- uspto-grants-2000_05
- 特許番号
- US06057349
反応ノート
読み込み中…