Ethanol → Ethyl 4-(aminomethyl)benzoate
反応式
[NH2:1][CH2:2][C:3]1[CH:11]=[CH:10][C:6]([C:7]([OH:9])=[O:8])=[CH:5][CH:4]=1.S(=O)(=O)(O)O.[CH2:17](O)[CH3:18]>>[NH2:1][CH2:2][C:3]1[CH:4]=[CH:5][C:6]([C:7]([O:9][CH2:17][CH3:18])=[O:8])=[CH:10][CH:11]=1参加物
4
実験手順
A mixture of 4-aminomethylbenzoic acid (25 g) and concentrated sulphuric acid (25 ml) in ethanol (250 ml) was heated at reflux for 18 hours. The volume of solvent was reduced to a third by evaporation. The residue was poured onto ice (500 g) and basified with concentrated aqueous ammonia. The product was extracted with ethyl acetate (3×200 ml) and the extracts dried and evaporated to give ethyl 4-aminomethylbenzoate.
後処理
- temperaturewas heated
- temperatureat reflux for 18 hours
- customThe volume of solvent was reduced to a third by evaporation
- additionThe residue was poured onto ice (500 g)
- extractionThe product was extracted with ethyl acetate (3×200 ml)
- customthe extracts dried
- customevaporated
出典と根拠
- ORDレコード
- ord-2f84f10dfc0b47cbb8e2ac3f5f312056
- 出典データセット
- uspto-grants-2000_05
- 特許番号
- US06057345
反応ノート
読み込み中…