Ammonia → (1-Phenylcyclohexyl)methanamine

HRID 1107439ノート

反応式

HRID 1107439 の反応式
[C:1]1([C:7]2([C:13]#[N:14])[CH2:12][CH2:11][CH2:10][CH2:9][CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.CCO.N>C(Cl)Cl.[Rh]>[C:1]1([C:7]2([CH2:13][NH2:14])[CH2:12][CH2:11][CH2:10][CH2:9][CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

参加物

6

反応物 3

HCID 222AmmoniaHCID 702EthanolHCID 751481-Phenylcyclohexanecarbonitrile

生成物 1

HCID 205110(1-Phenylcyclohexyl)methanamine

試薬・触媒・溶媒 2

HCID 23948Rhodium触媒HCID 6344Dichloromethane溶媒

実験手順

A mixture containing 1-phenyl-1-cyclohexane-carbonitrile (5.0 g, 27.0 mmol), 150 ml of EtOH, 35 ml of ammonia and 5% rhodium on alumina (1.0 g) was reacted for 12 hours at 80° C. and 500 psi. The mixture was filtered and the filtrate was concentrated in vacuo to provide an oil. This oil was dissolved in CH2Cl2, washed with brine, dried over Na2SO4, filtered and then concentrated in vacuo.

後処理

  1. customwas reacted for 12 hours at 80° C.
  2. filtrationThe mixture was filtered
  3. concentrationthe filtrate was concentrated in vacuo
  4. customto provide an oil
  5. washwashed with brine
  6. dry with materialdried over Na2SO4
  7. filtrationfiltered
  8. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-d56e7118374b4e1697b1196970ab8bfe
出典データセット
uspto-grants-2000_05
特許番号
US06060484

反応ノート

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