Hexadecylamine → N-(2-hydroxyethoxy)ethyl-n-hexadecylamine

HRID 1107605

反応式

HRID 1107605 の反応式
[CH2:1]([NH2:17])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH3:16].Cl[CH2:19][CH2:20][O:21][CH2:22][CH2:23][OH:24].[OH-].[K+].C(O)C>C(O)C>[OH:24][CH2:23][CH2:22][O:21][CH2:20][CH2:19][NH:17][CH2:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH3:16]

参加物

5

反応物 3

HCID 8926HexadecylamineHCID 123612-(Chloroethoxy)ethanolHCID 21946426Potassium hydroxide ethanol

生成物 1

HCID 9996690N-(2-hydroxyethoxy)ethyl-n-hexadecylamine収率 70%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

Into a 1 l rounded-flask, were introduced 48.2 g of hexadecyl amine and 700 ml of ethanol. The mixture was heated to reflux, and then was gradually added 11 ml of 2-(2-chloroethoxy)ethanol. The mixture was refluxed for 3 hours and cooled to a room temperature. Thereto was added solution of KOH/ethanol to produce precipitates, which were removed by filtration. The filtrate was concentrated under reduced pressure, and then was recrystallized from ethanol, and dried to give 24.1 g of the title compound(Yield: 70%) as white powder, which was identified by IR and NMR. The results are shown in Table 1.

後処理

  1. temperatureThe mixture was heated
  2. temperatureto reflux
  3. temperatureThe mixture was refluxed for 3 hours
  4. customto produce
  5. customprecipitates
  6. customwhich were removed by filtration
  7. concentrationThe filtrate was concentrated under reduced pressure
  8. customwas recrystallized from ethanol
  9. customdried

出典と根拠

ORDレコード
ord-7b93908ad6e64715811b802693a3f15e
出典データセット
uspto-grants-2000_05
特許番号
US06060612

関連ノート

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