Formamide → Ethyl 4-methyloxazole-5-carboxylate

HRID 1107695

反応式

HRID 1107695 の反応式
[CH2:1]([O:3][C:4](=[O:10])[CH:5](Cl)[C:6]([CH3:8])=O)[CH3:2].[CH:11]([NH2:13])=[O:12].C(=O)([O-])[O-].[K+].[K+]>>[CH2:1]([O:3][C:4]([C:5]1[O:12][CH:11]=[N:13][C:6]=1[CH3:8])=[O:10])[CH3:2]

参加物

4

反応物 3

HCID 713FormamideHCID 11430Potassium CarbonateHCID 11858Ethyl 2-chloroacetoacetate

生成物 1

HCID 88558Ethyl 4-methyloxazole-5-carboxylate収率 39.8%

反応条件

温度
120 °C

実験手順

To ethyl-2-chloroacetoacetate(5.6 g) was added formamide(4.6 g). The reaction mixture was stirred at 120° C. for 12 hours, cooled to 0° C. and aqueous potassium carbonate was added thereto. The mixture was extracted with benzene, dried with anhydrous magnesium sulfate, and concentrated in vacuo to obtain the target product(2.1 g).

後処理

  1. temperaturecooled to 0° C.
  2. extractionThe mixture was extracted with benzene
  3. dry with materialdried with anhydrous magnesium sulfate
  4. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-5df6a61042a447b080cb08964bf943f0
出典データセット
uspto-grants-2000_05
特許番号
US06063778

関連ノート

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