Dimethylamine → 2-bromo-N,N-dimethylbenzylamine

HRID 1107724

反応式

HRID 1107724 の反応式
[CH3:1][NH:2][CH3:3].[Br:4][C:5]1[CH:12]=[CH:11][CH:10]=[CH:9][C:6]=1[CH2:7]Br>CO>[Br:4][C:5]1[CH:12]=[CH:11][CH:10]=[CH:9][C:6]=1[CH2:7][N:2]([CH3:3])[CH3:1]

参加物

4

反応物 2

HCID 674DimethylamineHCID 769652-Bromobenzyl bromide

生成物 1

HCID 747922-bromo-N,N-dimethylbenzylamine

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

Dimethylamine (33% w/w in methanol) (25 ml) was added to 2-bromobenzylbromide (7.5 g 30 mmol) at 0° C. in methanol (35 ml), and the solution stirred for 30 min., evaporated, diluted with water and extracted twice with diethyl ether. The combined extracts were dried over sodium sulphate and evaporated to give product as a yellow oil (6.0 g). M+ 215/213; 360 MHz 1H n.m.r (CDCl3) 7.54 (1H, dd, J 1.2, 8.0 Hz), 7.42 (1H, dd, J 1.6, 7.6 Hz), 7.30-7.26 (1H, m), 7.11 (1H, dt, J 1.7, 7.7 Hz), 3.52 (2H, s), 2.30 (6H, s).

後処理

  1. customevaporated
  2. additiondiluted with water
  3. extractionextracted twice with diethyl ether
  4. dry with materialThe combined extracts were dried over sodium sulphate
  5. customevaporated

出典と根拠

ORDレコード
ord-df42aafd75f442d2b8d83ab3dd190459
出典データセット
uspto-grants-2000_05
特許番号
US06063789

関連ノート

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