(2-Chloro-6-fluorophenyl)methanethiol → HCID 54004521、化合物

反応式

[CH2:1]([N:5]1[C:9]2=[C:10](Cl)[N:11]=[N:12][CH:13]=[C:8]2[C:7]([CH3:15])=[C:6]1[CH3:16])[CH:2]=[CH:3][CH3:4].[Cl:17][C:18]1[CH:23]=[CH:22][CH:21]=[C:20]([F:24])[C:19]=1[CH2:25][SH:26]>>[CH2:1]([N:5]1[C:9]2=[C:10]([S:26][CH2:25][C:19]3[C:20]([F:24])=[CH:21][CH:22]=[CH:23][C:18]=3[Cl:17])[N:11]=[N:12][CH:13]=[C:8]2[C:7]([CH3:15])=[C:6]1[CH3:16])[CH:2]=[CH:3][CH3:4]

参加物

反応物 2

HCID 588756(2-Chloro-6-fluorophenyl)methanethiol

HCID 537196241-(2-Butenyl)-7-chloro-2,3-dimethylpyrrolo[2,3-d]pyridazine

生成物 1

HCID 54004521HCID 54004521、化合物収率 70.1%

実験手順

The title compound (cis/trans=18:82) was prepared as pale brown crystals in 70.1% yield in a similar procedure to that described in Example 1 by using 1-(2-butenyl)-7-chloro-2,3-dimethylpyrrolo[2,3-d]pyridazine (cis/trans=(22/78) and 2-chloro-6-fluorophenylmethanethiol.

出典と根拠

ORDレコード: ord-4f678882b70b45f794cd1c727d432d7c
出典データセット: uspto-grants-2000_05
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US06063782

反応ノート

読み込み中…

参加物