関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Ethanolamine | HCID 700 | — |
| 反応物 | Ethanol | HCID 702 | — |
| 反応物 | 1,2-Epoxyoctadecane | HCID 23872 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 1-(2-Hydroxyethylamino)-2-octadecanol | HCID 18332285 | 74.6% |
反応手順
A 300-ml flask equipped with a stirrer and a dropping funnel was charged with 45.8 g (0.75 mol) of ethanolamine and 9 g of ethanol. While stirring the mixture at 80° C., 13.4 g (50 mmol) of 1,2-epoxyoctadecane were added dropwise over 2 hours. Water was added to the resultant reaction mixture, and white crystals formed were collected by filtration, washed with water and then recrystallized from methanol, thereby obtaining 12.3 g (yield: 74.6%) of the title compound (IIc-1).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US05723497 |
|---|
| 出典データセット | uspto-grants-1998_03 |
|---|
| ORD ID | ord-80c2effe4d3141839b36b2e47237d5ac |
|---|
| 出典メモ | uspto-grants-1998_03 |
|---|
