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Triethylamine → 4'-[[(2,5-Dioxo-1-pyrrolidinyl)oxy]carbonyl][1,1'-biphenyl]-4-carbonyl chloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | [1,1'-Biphenyl]-4,4'-dicarbonyl dichloride | HCID 75374 | — |
| 反応物 | N-Hydroxysuccinimide | HCID 80170 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | 4'-[[(2,5-Dioxo-1-pyrrolidinyl)oxy]carbonyl][1,1'-biphenyl]-4-carbonyl chloride | HCID 18407509 | 93.2% |
反応手順
A solution of 1.67 g (6.0 mmol) of 11 in 65 mL of dry THF was treated with 710 mg (6.17 mmol) of N-hydroxysuccinimide, followed by 0.835 mL (6.0 mmol) of triethylamine. The reaction was stirred at room temperature for 2 hours after which time it was filtered to remove triethylamine HCl. The filtrate was concentrated at reduced pressure to yield 2.0 g (93%) of 12 as a pale yellow solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06063908 |
| 出典データセット | uspto-grants-2000_05 |
| ORD ID | ord-61f6197dc95546399c5d531483c2f2d7 |
| 出典メモ | uspto-grants-2000_05 |