Methanol → 2-(2-Acetoxyethyl)thio-2',4'-difluoroacetophenone

反応式

Cl[CH2:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([F:11])=[CH:7][C:6]=1[F:12])=[O:4].[C:13]([O:16][CH2:17][CH2:18][SH:19])(=[O:15])[CH3:14].C(=O)([O-])[O-].[K+].[K+].CO>>[C:13]([O:16][CH2:17][CH2:18][S:19][CH2:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([F:11])=[CH:7][C:6]=1[F:12])=[O:4])(=[O:15])[CH3:14]

参加物

反応物 4

HCID 887Methanol

HCID 11430Potassium Carbonate

HCID 98505Ethanol, 2-mercapto-, 1-acetate

HCID 5880832-Chloro-1-(2,4-difluorophenyl)ethanone

生成物 1

HCID 106599152-(2-Acetoxyethyl)thio-2',4'-difluoroacetophenone収率 65.6%

実験手順

Using 2-chloro-2',4'-difluoroacetophenone (2.0 g, 0.010 mol), 2-acetoxyethanethiol (J. Chem. Soc., 1952, 817.) (1.5 g, 0.013 mol), potassium carbonate (1.8 g, 0.013 mol) and methanol (50 mol), 2-(2-acetoxyethyl)thio-2',4'-difluoroacetophenone (1.8 g, yield: 62.0%) was obtained as a colorless oil by similar procedures to Example 1.