Carbon tetrabromide → 4-Bromo-2-bromomethyl-7-methoxybenzofuran
反応式
[C:1]([Br:5])(Br)(Br)Br.[Br:6][C:7]1[C:12]2[CH:13]=[C:14](CO)[O:15][C:11]=2[C:10]([O:18][CH3:19])=[CH:9][CH:8]=1.C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1>ClCCl>[Br:6][C:7]1[C:12]2[CH:13]=[C:14]([CH2:1][Br:5])[O:15][C:11]=2[C:10]([O:18][CH3:19])=[CH:9][CH:8]=1参加物
5
実験手順
Carbon tetrabromide (1.52 g) was added to a stirred solution of (4-bromo-7-methoxybenzofuran-2-yl)-methanol (1 g) in dichloromethane (10 ml) at 0° C. under an inert atmosphere. Triphenylphosphine (1.53 g) was then added and the reaction stirred for 1 h. The reaction mixture was preadsorbed onto silica and purified by column chromatography eluting with 25% ethyl acetate in hexane to afford the title compound as a yellow solid (0.78 g).
後処理
- custompurified by column chromatography
- washeluting with 25% ethyl acetate in hexane
出典と根拠
- ORDレコード
- ord-e55d8e4de56b4819bfd6913dc5e6b8b7
- 出典データセット
- uspto-grants-2000_05
- 特許番号
- US06066657
反応ノート
読み込み中…