Diisobutylaluminum hydride → 5-Ethoxypyridine-3-carbaldehyde
反応式
[CH2:1]([O:3][C:4]1[CH:5]=[N:6][CH:7]=[C:8]([CH:15]=1)[C:9](N(OC)C)=[O:10])[CH3:2].CC(C[AlH]CC(C)C)C>C(Cl)Cl>[CH2:1]([O:3][C:4]1[CH:15]=[C:8]([CH:9]=[O:10])[CH:7]=[N:6][CH:5]=1)[CH3:2]参加物
4
反応条件
- 温度
- 0 °C
実験手順
To a stirred solution of 16-3 (14.0 g, 66.5 mmol) and CH2Cl2 (200 mL) at -78° C. under argon was added DIBAL (1.0M hexanes, 90 ml) dropwise over 30 minutes. After 30 minutes, the solution was warmed to 0° C. for 1 hour. The reaction was quenched with 100 ml 1.0M Rochelle's salt, stirred for 1.0 hour and then extracted with Et2O. The organic layer was dried (MgSO4), and then concentrated to give the aldehyde 16-4 as a brown oil.
後処理
- customThe reaction was quenched with 100 ml 1.0M Rochelle's salt
- extractionextracted with Et2O
- dry with materialThe organic layer was dried (MgSO4)
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-0d5bb1b1f61a4a458a15e8e99ffe20ef
- 出典データセット
- uspto-grants-2000_05
- 特許番号
- US06066648
反応ノート
読み込み中…