Hydrochloric Acid → HCID 18785143、化合物

HRID 1108496ノート

反応式

HRID 1108496 の反応式
C(OC([N:8]1[C:12]2[C:13]([F:19])=[CH:14][C:15]([NH2:18])=[C:16]([CH3:17])[C:11]=2[N:10]=[CH:9]1)=O)(C)(C)C.[ClH:20]>>[ClH:20].[CH3:17][C:16]1[C:11]2[NH:10][CH:9]=[N:8][C:12]=2[C:13]([F:19])=[CH:14][C:15]=1[NH2:18]

参加物

3

反応物 2

HCID 313Hydrochloric AcidHCID 18785142HCID 18785142、化合物

生成物 1

HCID 18785143HCID 18785143、化合物

実験手順

1-tert-Butoxycarbonyl-4-methyl-5-amino-7-fluorobenzimidazole (1 g) (prepared as described in U.S. Pat. No. 5,478,858 issued to Cupps and Bogdan, Dec. 26, 1995, incorporated herein by reference) and 6N HCl (10 mL) are combined and heated to reflux while stirring. After completion of the t-BOC group deprotection, the reaction mixture is concentrated under reduced pressure and dried to furnish 4methyl-5-amino-7-fluorobenzimidazole hydrochloride.

後処理

  1. temperatureheated
  2. temperatureto reflux
  3. concentrationAfter completion of the t-BOC group deprotection, the reaction mixture is concentrated under reduced pressure
  4. customdried

出典と根拠

ORDレコード
ord-25207606004a45c7b45f8040b0f4e281
出典データセット
uspto-grants-2000_05
特許番号
US06066740

反応ノート

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