Hydroquinone → 1-(2-Methacryloyloxyethyl)indole

HRID 1108540ノート

反応式

HRID 1108540 の反応式
Cl[CH2:2][CH2:3][N:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[CH:6]=[CH:5]1.[C:13]([O-:18])(=[O:17])[C:14]([CH3:16])=[CH2:15].[K+].[I-].[K+].C1(C=CC(O)=CC=1)O>CN(C)C=O>[C:13]([O:18][CH2:2][CH2:3][N:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[CH:6]=[CH:5]1)(=[O:17])[C:14]([CH3:16])=[CH2:15]

参加物

6

反応物 4

HCID 785HydroquinoneHCID 4875Potassium IodideHCID 108992601-(2-chloroethyl)-1H-indoleHCID 23667354Potassium methacrylate

生成物 1

HCID 184697791-(2-Methacryloyloxyethyl)indole収率 78.9%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

反応条件

温度
100 °C

実験手順

Subsequently, 1-(2-chloroethyl)indole (15.4 g), potassium methacrylate (21.3 g), potassium iodide (7.1 g), N,N-dimethylformamide (40 ml), and a small amount of hydroquinone were placed in a 200-ml flask equipped with a stirrer and a condenser tube. The mixture was heated to 100° C. and stirred for 2.5 hours. After completion of reaction, insoluble matter was removed by filtration, and the filtrate was concentrated under reduced pressure. This reaction mixture was purified further by silica gel column chromatography to obtain 1-(2-methacryloyloxyethyl) indole (15.5 g).

後処理

  1. customequipped with a stirrer and a condenser tube
  2. customAfter completion of reaction, insoluble matter
  3. customwas removed by filtration
  4. concentrationthe filtrate was concentrated under reduced pressure
  5. customThis reaction mixture was purified further by silica gel column chromatography

出典と根拠

ORDレコード
ord-cbd6d095bfb2494e95f2835fc96b22b3
出典データセット
uspto-grants-2000_05
特許番号
US06068963

反応ノート

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