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Methyl 3,4-Dimethoxybenzoate → N-(3,4-Dimethoxybenzoyl)-2-(3-methylphenyl) ethylamine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methyl 3,4-Dimethoxybenzoate | HCID 16522 | — |
| 反応物 | 2-(3-Methylphenyl)ethan-1-amine | HCID 410085 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | N-(3,4-Dimethoxybenzoyl)-2-(3-methylphenyl) ethylamine | HCID 15068903 | 51% |
反応手順
A stirred solution of 2-(3-methylphenyl) ethylamine (28.3 g, 0.21 mol) and 36.9 g of methyl 3, 4-dimethoxybenzoate (36.9 g, 0.19 mol) was heated at 180° for 4 h. The crude amide was taken up in CH2Cl2 and washed with dilute HCl, dilute Na2CO3 and water. Chromatography over neutral alumina afforded 29 g (51%) of the title compound (one spot by tlc) eluted with CH2Cl2. The analytical sample showed mp 108°-109 after crystallization from i-PrOH.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | USRE034630 |
| 出典データセット | uspto-grants-1994_06 |
| ORD ID | ord-6dd328baf333427dbc68b8b470d564cd |
| 出典メモ | uspto-grants-1994_06 |