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Sodium Hydroxide → 3'-Amino-4'-hydroxyacetophenone
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | Sodium Dithionite | HCID 24489 | — |
| 反応物 | 4-Hydroxy-3-Nitroacetophenone | HCID 138723 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 3'-Amino-4'-hydroxyacetophenone | HCID 13724142 | 39.1% |
反応手順
In a 300 ml-three-necked flask, 5.00 g (27.6 mM) of 2-nitro-4-acetylphenol was 75 ml of 2N-sodium hydroxide aqueous solution were placed. To the mixture, a solution of 25.00 g of sodium hydrosulfite (Na2S2O4) in 75 ml of water was added dropwise in 10 minutes, followed by stirring for 20 minutes at room temperature to precipitate a crystal. The crystal was recovered by filtration and recrystallized from a mixture solvent (methanol-water) to obtain 1.63 g of 2-amino-4-acetylphenol (Yield: 39.1%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05318720 |
| 出典データセット | uspto-grants-1994_06 |
| ORD ID | ord-0626082b2c6042f8b9ac06cd68658d77 |
| 出典メモ | uspto-grants-1994_06 |