関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Sulfuric Acid | HCID 1118 | — |
| 反応物 | p-Toluenesulfonic acid | HCID 6101 | — |
| 反応物 | Sodium Bicarbonate | HCID 516892 | — |
| 反応物 | H-Orn(Z)-OH | HCID 7009570 | — |
| 溶媒 | Water | HCID 962 | — |
| 溶媒 | tert-Butyl acetate | HCID 10908 | — |
| 生成物 | N5-benzyloxycarbonyl-ornithine, t-butyl ester | HCID 7019766 | — |
反応手順
Suspend N5 -benzyloxycarbonyl-ornithine (80 g, 0.3 mol) in t-butyl acetate (250 mL) and cool to 10° C. Add p-toluenesulfonic acid (57 g, 0.3 mol) and add, by dropwise addition, concentrated sulfuric acid (80 mL). Stir at 10° C. until the reaction is complete, basify to pH 8 by adding a suspension of sodium bicarbonate in water. Extract with ethyl acetate, dry (MgSO4), and evaporate to give N5 -benzyloxycarbonyl-ornithine, t-butyl ester.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US05318992 |
|---|
| 出典データセット | uspto-grants-1994_06 |
|---|
| ORD ID | ord-45555e6d55c24eb3af47a6ec852f723c |
|---|
| 出典メモ | uspto-grants-1994_06 |
|---|
