関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Ammonium Hydroxide | HCID 14923 | — |
| 反応物 | 2,2-Dimethylvaleroyl chloride | HCID 519171 | — |
| 生成物 | 2,2-Dimethylpentanamide | HCID 83180 | 86% |
反応手順
Ammonium hydroxide (250 ml) was stirred and cooled to 1° C. and 2,2-dimethyl valeroyl chloride (49.7 g, 95%, 318 mmol) was added dropwise over 30 minutes. After stirring at room temperature for an additional 1/2 hour, the white solid product was recovered by filtration, washed with water and allowed to air dry to give 35.4 g (86%) of the desired amide, mp 94°-95° (lit. mp 95°-96° C.).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US05319133 |
|---|
| 出典データセット | uspto-grants-1994_06 |
|---|
| ORD ID | ord-3a9e20c6bbea417cae8668dd93d16f00 |
|---|
| 出典メモ | uspto-grants-1994_06 |
|---|
