Triphenylphosphine → Triphenyl[3-(3,4,5-trimethoxyphenyl)propyl]phosphonium bromide

HRID 1109659ノート

反応式

HRID 1109659 の反応式
[Br:1][CH2:2][CH2:3][CH2:4][C:5]1[CH:6]=[C:7]([O:15][CH3:16])[C:8]([O:13][CH3:14])=[C:9]([O:11][CH3:12])[CH:10]=1.[C:17]1([P:23]([C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=2)[C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1>C1(C)C=CC=CC=1>[Br-:1].[C:30]1([P+:23]([C:17]2[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=2)([C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)[CH2:2][CH2:3][CH2:4][C:5]2[CH:6]=[C:7]([O:15][CH3:16])[C:8]([O:13][CH3:14])=[C:9]([O:11][CH3:12])[CH:10]=2)[CH:31]=[CH:32][CH:33]=[CH:34][CH:35]=1

参加物

4

反応物 2

HCID 11776TriphenylphosphineHCID 226096115-(3-Bromopropyl)-1,2,3-trimethoxybenzene

生成物 1

HCID 19020969Triphenyl[3-(3,4,5-trimethoxyphenyl)propyl]phosphonium bromide収率 51%

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

Dissolved in 50 ml of toluene were 7.65 g (26.5 mmol) of 5-(3-bromopropyl)-1,2,3-trimethoxybenzene and 6.9 g (26.5 mmol) of triphenylphosphine, followed by heating under reflux for 23 hours. The reaction mixture was allowed to cool down to room temperature. The supernatant was thereafter removed by decantation, whereby 7.46 g of crude triphenyl[3-(3,4,5-trimethoxyphenyl)propyl]phosphonium bromide were obtained as colorless oil (yield: 51%). The crude oil was used in the next reaction without purification.

後処理

  1. temperatureby heating
  2. temperatureunder reflux for 23 hours
  3. customThe supernatant was thereafter removed by decantation

出典と根拠

ORDレコード
ord-8850c8388fe348f0bd51a5abf843c299
出典データセット
uspto-grants-1994_06
特許番号
US05321135

反応ノート

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