Triethylamine → Octadecyl 3-(4-Amino-3-tert-butyl-5-methylphenylthio)propionate

HRID 1109669

反応式

HRID 1109669 の反応式
[C:1]([C:5]1[CH:11]=[C:10]([SH:12])[CH:9]=[C:8]([CH3:13])[C:6]=1[NH2:7])([CH3:4])([CH3:3])[CH3:2].[C:14]([O:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH3:36])(=[O:17])[CH:15]=[CH2:16].C(N(CC)CC)C>C1(C)C=CC=CC=1>[NH2:7][C:6]1[C:8]([CH3:13])=[CH:9][C:10]([S:12][CH2:16][CH2:15][C:14]([O:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH3:36])=[O:17])=[CH:11][C:5]=1[C:1]([CH3:4])([CH3:3])[CH3:2]

参加物

5

反応物 3

HCID 8471TriethylamineHCID 62552Stearyl acrylateHCID 153245012-Tert-butyl-4-mercapto-6-methylaniline

生成物 1

HCID 15324508Octadecyl 3-(4-Amino-3-tert-butyl-5-methylphenylthio)propionate収率 72%

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

A stirred solution of 4.5 g (23 mmol) of 2-tert-butyl-4-mercapto-6-methylaniline, 7.5 g (23 mmol) of octadecyl acrylate and 0.2 g (2 mmol) of triethylamine in 50 mL of toluene is heated at 50° C. for 18 hrs. The solvent is removed in vacuo and the residue is purified by preparative HPLC (silica gel, 9:1, heptane:ethyl acetate eluent) to give 8.6 g (72%) of the title compound as a colorless liquid.

後処理

  1. customThe solvent is removed in vacuo
  2. customthe residue is purified by preparative HPLC (silica gel, 9:1, heptane:ethyl acetate eluent)

出典と根拠

ORDレコード
ord-0e48a283467a4669abd47bb264a069c2
出典データセット
uspto-grants-1994_06
特許番号
US05321067

関連ノート

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