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Benzyl Alcohol → 3-(5-Fluorobenzothiazol-2-yl-trans-ethenyl)benzyl alcohol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Benzyl Alcohol | HCID 244 | — |
| 反応物 | Acetic Anhydride | HCID 7918 | — |
| 反応物 | Isophthalaldehyde | HCID 34777 | — |
| 反応物 | 5-Fluoro-2-methylbenzothiazole | HCID 597437 | — |
| 反応物 | Sodium borohydride | HCID 4311764 | — |
| 反応物 | 3-(5-Fluorobenzothiazol-2-yl-trans-ethenyl)benzaldehyde | HCID 86747932 | — |
| 触媒 | Zincchloride | HCID 3007855 | — |
| 溶媒 | O-Xylene | HCID 7237 | — |
| 生成物 | 3-(5-Fluorobenzothiazol-2-yl-trans-ethenyl)benzyl alcohol | HCID 67828433 | — |
反応手順
An alternate procedure for preparing this benzyl alcohol comprises condensing isophthalaldehyde with 2-methyl-5-fluorobenzothiazole in the presence of acetic anhydride and zinc chloride in hot xylene followed by the reduction of the 3-(5-fluorobenzothiazol-2-yl-trans-ethenyl)benzaldehyde product with sodium borohydride to provide the appropriate benzyl alcohol.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05322847 |
| 出典データセット | uspto-grants-1994_06 |
| ORD ID | ord-bebd70f669a54af8be82f17d90119462 |
| 出典メモ | uspto-grants-1994_06 |