2-Chloroethanol → 1-Chloro-3-(2-chloroethoxy)propan-2-ol

A mixture consisting of 100 g 2-chloroethanol (12.4 mol), 573 g epichlorohydrin (6.2 mol) and 20 g of an acidic ion exchange resin was refluxed for 24 hours. The mixture was then filtered to remove the ion exchange resin and the excess alcohol and unreacted epichlorohydrin were removed by distillation. The residue was distilled under vacuum and the product 1-chloro-3-(2-chloroethoxy)-2-propanol (804 g, 75% yield) distilled between 89 and 91° C. at 0.05mm Hg.

1. temperaturewas refluxed for 24 hours
2. filtrationThe mixture was then filtered
3. customto remove the ion exchange resin
4. customthe excess alcohol and unreacted epichlorohydrin were removed by distillation
5. distillationThe residue was distilled under vacuum

ORDレコード

ord-0d6ae4e16ebf457aa7b1a2026bef9763

出典データセット

uspto-grants-1994_06

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US05322904