化工社化工社 化学情報印刷レポート · 研究参考用
Decanoyl chloride → 6,12,18-Tris(benzyloxy)-7,13,19-trioxo-6,12,18-triazaoctacosanenitrile
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Decanoyl chloride | HCID 66982 | — |
| 反応物 | 6,12,18-Tris(benzyloxy)-7,13-dioxo-6,12,18-triazaoctadecanenitrile | HCID 9986266 | — |
| 反応物 | N-(Benzyloxy)-N-(4-cyanobutyl)-5-chloropentanamide | HCID 10087530 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 溶媒 | Sodium Hydroxide | HCID 14798 | — |
| 生成物 | 6,12,18-Tris(benzyloxy)-7,13,19-trioxo-6,12,18-triazaoctacosanenitrile | HCID 10417720 | 80% |
反応手順
Compound (8) (1.20 g, 1.95 mmol) was reacted with decanoyl chloride (0,565 g, 2.96 mmol) in CH2Cl2 and 1N NaOH following the procedure used for (3). Purification by silica gel column chromatography with 2:1 EtOAc/hexane as the eluant provided 1.20 g (80%) of (10) as an oil: NMR δ 0.90 (t, 3 H, J=6), 1.13-1.40 (m, 14 H), 1.47-1.90 (m, 12 H), 2.23-2.53 (m, 8 H), 3.50-3.77 (m, 6 H), 4.77 (s, 6 H), 7.33 (s, 15 H). Anal. (C46H64N4O6) C, H, N.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05322961 |
| 出典データセット | uspto-grants-1994_06 |
| ORD ID | ord-1cf28dfbeaa947d09f23a683925786c7 |
| 出典メモ | uspto-grants-1994_06 |