Ethanol → ethyl quinoline-2-carboxylate

HRID 1110026ノート

反応式

HRID 1110026 の反応式
[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[C:11]([OH:13])=[O:12].S(=O)(=O)(O)O.[CH2:19](O)[CH3:20]>>[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[C:11]([O:13][CH2:19][CH3:20])=[O:12]

参加物

4

反応物 3

HCID 702EthanolHCID 1118Sulfuric AcidHCID 7124Quinaldic Acid

生成物 1

HCID 421739ethyl quinoline-2-carboxylate

実験手順

29.89 g of quinoline-2-carboxylic acid were heated under reflux for 51/2 hours in 450 ml of ethanol with the addition of 3.5 ml of sulfuric acid. The reaction mixture was worked up by evaporating it, taking up the residue in water and extracting the mixture with dichloromethane. The organic phase was washed with aqueous sodium bicarbonate solution and then with water until neutral, dried and evaporated. 32.23 g of crude ethyl quinoline-2-carboxylate were obtained as a green oil.

後処理

  1. customby evaporating it
  2. extractionextracting the mixture with dichloromethane
  3. washThe organic phase was washed with aqueous sodium bicarbonate solution
  4. dry with materialwith water until neutral, dried
  5. customevaporated

出典と根拠

ORDレコード
ord-976e133b766b461e9cb7d0504ebe0de8
出典データセット
uspto-grants-1994_06
特許番号
US05324725

反応ノート

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