Hydrochloric Acid → Spiro[indene-1,4'-piperidine] hydrochloride

HRID 1110038ノート

反応式

HRID 1110038 の反応式
C(OC([N:8]1[CH2:13][CH2:12][C:11]2([C:21]3[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=3)[CH:15]=[CH:14]2)[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:22]>C(OCC)(=O)C>[ClH:22].[NH:8]1[CH2:13][CH2:12][C:11]2([C:21]3[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=3)[CH:15]=[CH:14]2)[CH2:10][CH2:9]1

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 3653579Tert-butyl Spiro[indene-1,4'-piperidine]-1'-carboxylate

生成物 1

HCID 22509344Spiro[indene-1,4'-piperidine] hydrochloride収率 99%

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒

実験手順

A solution of 1'-(tert-butyloxycarbonyl)spiro [indene-1,4'-piperidine] (3.0 g, 0.011 mol) in ethyl acetate (150 ml) was stirred at 0° C., and treated with hydrogen chloride for 30 minutes. The mixture was then evaporated to dryness, ethyl acetate (100 ml) was added, then removed in vacuo three times. The residue was stirred with anhydrous ether (200 ml), and the solid filtered off, to give spiro[indene-1,4'-piperidine] hydrochloride (2.3 g, 99%) as a pale yellow solid. The product was not purified further.

後処理

  1. customThe mixture was then evaporated to dryness, ethyl acetate (100 ml)
  2. additionwas added
  3. customremoved in vacuo three times
  4. filtrationthe solid filtered off

出典と根拠

ORDレコード
ord-ad79964c21e64bd3b773478810b12fed
出典データセット
uspto-grants-1994_06
特許番号
US05324733

反応ノート

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