Phosgene → N,N-dimethyl-2-chloro-5-isocyanatobenzenesulfonamide

HRID 1110147ノート

反応式

HRID 1110147 の反応式
[CH3:1][N:2]([CH3:14])[S:3]([C:6]1[CH:11]=[C:10]([NH2:12])[CH:9]=[CH:8][C:7]=1[Cl:13])(=[O:5])=[O:4].[C:15](Cl)(Cl)=[O:16]>C(OCC)(=O)C>[CH3:1][N:2]([CH3:14])[S:3]([C:6]1[CH:11]=[C:10]([N:12]=[C:15]=[O:16])[CH:9]=[CH:8][C:7]=1[Cl:13])(=[O:5])=[O:4]

参加物

4

反応物 2

HCID 6371PhosgeneHCID 36139385-amino-2-chloro-N,N-dimethylbenzene-1-sulfonamide

生成物 1

HCID 18993674N,N-dimethyl-2-chloro-5-isocyanatobenzenesulfonamide

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒

実験手順

50 g of N,N-dimethyl-2-chloro-5-aminobenzenesulfonamide (Example A-3 above) was treated with an excess of phosgene in ethyl acetate as is generally described in "Organic Functional Group Preparations" by S. R. Sandler and W. Karo on pages 364-365 (Academic Press, N.Y., 1983) (preparation of organic isocyanates), which disclosure is herein incorporated by reference. 48 g of the title compound was isolated as a tan solid with a melting point of 82°-85° C.

出典と根拠

ORDレコード
ord-308ba372b6764dab8bbf556012872b05
出典データセット
uspto-grants-1994_06
特許番号
US05324854

反応ノート

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