Ammonia → 2-Cyanoethyl 3-amino-2-butenoate
反応式
[C:1]([O:7][CH2:8][CH2:9][C:10]#[N:11])(=[O:6])[CH2:2][C:3]([CH3:5])=O.[NH3:12]>CO>[NH2:12][C:3]([CH3:5])=[CH:2][C:1]([O:7][CH2:8][CH2:9][C:10]#[N:11])=[O:6]参加物
4
実験手順
To 10 mL of methanol was added 20 g (0.13 mole) of 2-cyanoethyl acetoacetate. The solution was cooled in ice and a slow stream of ammonia gas was passed through it for five hours. The reaction flask was stoppered and stored at 0° C. overnight. The resulting solid was collected, washed with a small amount of methanol and dried under high vacuum to give 11.1 g (0.072 mole) of 2-cyanoethyl 3-aminobut-2-enoate, 1H NMR 4.6 (s, 1H), 4.3 (t, 2H), 2.8 (t, 2H), 2.0(t, 3H).
後処理
- temperatureThe solution was cooled in ice
- customThe resulting solid was collected
- washwashed with a small amount of methanol
- customdried under high vacuum
出典と根拠
- ORDレコード
- ord-659da49c72a340e59d6911e1e26c0d8c
- 出典データセット
- uspto-grants-1990_12
- 特許番号
- US04975437
反応ノート
読み込み中…