Ethanol → Ethyl 4-(hydroxymethyl)benzoate

HRID 1110414

反応式

HRID 1110414 の反応式
[OH:1][CH2:2][C:3]1[CH:11]=[CH:10][C:6]([C:7]([OH:9])=[O:8])=[CH:5][CH:4]=1.S(=O)(=O)(O)O.[CH2:17](O)[CH3:18]>>[OH:1][CH2:2][C:3]1[CH:4]=[CH:5][C:6]([C:7]([O:9][CH2:17][CH3:18])=[O:8])=[CH:10][CH:11]=1

参加物

4

反応物 3

HCID 702EthanolHCID 1118Sulfuric AcidHCID 763604-(Hydroxymethyl)benzoic acid

生成物 1

HCID 12480307Ethyl 4-(hydroxymethyl)benzoate

実験手順

4 g (26.3 mmol) of 4-(hydroxymethyl)benzoic acid in 1,000 ml of absolute ethanol are heated under reflux of the solvent for 15 hours in the presence of approximately 1 g of concentrated sulfuric acid. The ethyl alcohol is then evaporated off and the residue taken up with water. After extraction of the aqueous phase with 3×100 ml of ethyl ether, the organic phases are washed to neutrality with saturated sodium hydrogen carbonate solution. After removal of the solvent, 4.56 g of a yellow oil, which soon crystallizes, remains.

後処理

  1. customThe ethyl alcohol is then evaporated off
  2. extractionAfter extraction of the aqueous phase with 3×100 ml of ethyl ether
  3. washthe organic phases are washed to neutrality with saturated sodium hydrogen carbonate solution
  4. customAfter removal of the solvent, 4.56 g of a yellow oil, which
  5. customsoon crystallizes

出典と根拠

ORDレコード
ord-847f296432e94bd58988b2c7c83018ef
出典データセット
uspto-grants-1990_12
特許番号
US04975455

関連ノート

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