Ethyl 4-(hydroxymethyl)benzoate → Ethyl 4-formylbenzoate

HRID 1110415

反応式

HRID 1110415 の反応式
[OH:1][CH2:2][C:3]1[CH:13]=[CH:12][C:6]([C:7]([O:9][CH2:10][CH3:11])=[O:8])=[CH:5][CH:4]=1>[O-2].[O-2].[Mn+4].CCCCCC.C(Cl)(Cl)(Cl)Cl>[CH:2]([C:3]1[CH:13]=[CH:12][C:6]([C:7]([O:9][CH2:10][CH3:11])=[O:8])=[CH:5][CH:4]=1)=[O:1]

参加物

4

反応物 1

HCID 12480307Ethyl 4-(hydroxymethyl)benzoate

生成物 1

HCID 80498Ethyl 4-formylbenzoate

試薬・触媒・溶媒 2

HCID 178418406HCID 178418406、化合物触媒HCID 21584008HCID 21584008、化合物溶媒

実験手順

24.1 g (0.277 mmol) of manganese dioxide are added with stirring and at room temperature to a solution of 2.5 g (13.9 mmol) of ethyl 4-(hydroxymethyl)benzoate in an n-hexane/carbon tetrachloride (50 ml : 30 ml) mixture. After half an hour of stirring, the reaction is complete. After filtration of the reaction medium and removal of the solvents under vacuum, 1.76 g of a yellow oil which gives a single spot in TLC are obtained. A crystallization in isopropyl ether yields a white solid.

後処理

  1. filtrationAfter filtration of the reaction medium and removal of the solvents under vacuum, 1.76 g of a yellow oil which
  2. customgives a single spot in TLC
  3. customare obtained
  4. customA crystallization in isopropyl ether
  5. customyields a white solid

出典と根拠

ORDレコード
ord-32048ce8316e457bb1c9fc001742ff4b
出典データセット
uspto-grants-1990_12
特許番号
US04975455

関連ノート

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